|
KMID : 0363620090300060009
|
|
Journal of Korean Oriental Medicine
2009 Volume.30 No. 6 p.9 ~ p.16
|
|
|
The Effects of Jungri-tang Gamibang on Carbachol-accelerated Mouse Small Intestinal Transit
|
|
Kim Dae-Jun
Byun Joon-Seok
|
|
|
Abstract
|
|
|
Objectives: To clarify the effects of Jungri-tang Gamibang on accelerating small intestinal movement induced by the stimulation of cholinergic neurotransmission.
Methods: 500, 250 and 125mg Jungri-Tang Gamibang or 20mg domperidone were dissolved or suspended in distilled water and orally pretreated on the carbachol-accelerated small intestinal transit mice once a day for 7 days at a volume of 10ml/kg (of body weight) using a Zonde needle attached to 1 ml syringes containing test drugs.
Result: Significantly (p<0.01) increase of % regions of activated charcoal transit in the small intestine was detected in carbachol control compared to that of intact control. However, significant (p<0.01) decreases of % regions of activated charcoal transit were dose-dependently observed in all Jungri-Tang Gamibang extracts or domperidone-pretreated groups.
Conclusions: it was concluded that Jungri-tang Gamibang enhancement in the normal intestinal motility and normalization in the accelerated intestinal motility might interfere with a variety of muscarinic, adrenergic and histaminic receptor activities or with the mobilization of calcium ions required for smooth muscle contraction non-specifically.
|
|
|
KEYWORD
|
|
|
Jungri-tang, antispasmodic effects, domperidone
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|